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http://smartcomputing123.blogspot.com/2012/10/the-information-technology-it.html :
This separation strategy is most often used when physical Assets are involved and need to be separated. The separation of facilities, such as keeping things in different rooms, allows for tangible or physical Assets to be kept away from each other and eliminates things like comingling. Examples of isolated physical locations include "Clean Rooms," which are used in the research, manufacturing and testing of semiconductors.

https://restservice.epri.com/publicdownload/000000003002026499/0/Product : separation of nuclear facilities from adjacent facilities